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The present study aimed to investigate the neuroprotective effect and potential mechanism of ginsenoside Rg1 (GRg1) on brain neuron survival, learning, and memory in rats with transient global cerebral ischemia. We randomly divided 81 Wistar rats into six groups: sham, global cerebral ischemia and reperfusion (Global-I/R), GRg1, and nimodipine (Nim) groups. Rats in the GRg1 and Nim groups were administered 5 and 5 mg/kg of GRg1 and Nim (i.p.), respectively, at a dose of 25 mg/kg, immediately after reperfusion. Rats in the sham and Global-I/R groups were administered distilled water. The Morris Water Maze 0b46394aab